At the close of the CMIO Leadership Forum: Transforming Healthcare Through Evidence-based Medicine, we invited five luminaries to build on the abundant discussions and dive deeper into the quality of the evidence in medicine, the lack of evidence in many cases, the struggle to engage physicians and patients, and strategies for integrating evidence-based medicine (EBM) into clinical practice. Will the adoption of EBM reach 90 percent by 2020? Should evidence-based medicine be expanded to evidence-based healthcare? Will we see the rise of EBM as a medical specialty? Read on to find out.